ACLS Sample Questions

ACLS Sample Questions & Answers

The cardiac arrest algorithm gets the heaviest emphasis, covering shockable and non-shockable rhythms and return of circulation, alongside CPR teamwork, bradycardia and tachycardia protocols, acute coronary syndromes, stroke recognition, and airway management.

Launch the full ACLS simulator →

Showing 9 of 19 free samples.

  1. Question 1Intermediate

    Bradycardia Management · Atropine-Refractory Bradycardia

    A 55-year-old female presents with symptomatic bradycardia at a rate of 40/min. She is diaphoretic and has a BP of 88/50 mmHg. The monitor shows a third-degree AV block. Two doses of atropine 1 mg IV have been administered with no improvement. What is the next most appropriate intervention?

    Show answer & explanation

    Correct answer: B

    The patient is exhibiting symptomatic bradycardia with a high-degree AV block that is refractory to atropine. According to the ACLS bradycardia algorithm, the next step is transcutaneous pacing. If TCP is ineffective or not immediately available, a chronotropic agent infusion like dopamine or epinephrine would be the next consideration. Atropine is unlikely to be effective in third-degree block and further doses are not indicated.

  2. Question 2Beginner

    High-Quality CPR and BLS · Quantitative Waveform Capnography

    A hospital's resuscitation quality improvement committee is reviewing data from recent cardiac arrest events. They want to assess the effectiveness of chest compressions using quantitative waveform capnography. Which ETCO2 value is the minimum threshold that indicates high-quality CPR?

    Show answer & explanation

    Correct answer: B

    During CPR for an intubated patient, an end-tidal CO2 (ETCO2) value of at least 10 mmHg is the minimum target to indicate high-quality chest compressions. Values below this suggest inadequate perfusion and should prompt an evaluation of CPR technique, including compression depth, rate, and recoil. While higher values are better, 10 mmHg is the critical threshold.

  3. Question 3Intermediate

    Suspected Stroke · Fibrinolytic Therapy Window

    A patient arrives at the emergency department with symptoms suggestive of an acute stroke. The initial non-contrast CT scan of the head is negative for hemorrhage. The patient meets all other criteria for fibrinolytic therapy. According to the ACLS Suspected Stroke Algorithm, fibrinolytic therapy (tPA) should be administered within what timeframe from the onset of symptoms?

    Show answer & explanation

    Correct answer: C

    The standard window for administering intravenous tissue plasminogen activator (tPA) for acute ischemic stroke is within 3 hours of symptom onset for most eligible patients. This window can be extended to 4.5 hours for a select group of patients, but the 3 to 4.5-hour timeframe is the critical period emphasized in ACLS protocols. Time is brain, and earlier administration leads to better outcomes.

  4. Question 4Advanced

    Acute Coronary Syndromes (ACS) · STEMI Management

    Case Study

    A 72-year-old male is brought to the ED with a chief complaint of severe, crushing substernal chest pain that began 45 minutes ago. He has a history of hypertension and type 2 diabetes. His initial vital signs are BP 160/95 mmHg, HR 95 bpm, RR 22/min, and SpO2 96% on room air. He is given 324 mg of aspirin to chew.

    A 12-lead ECG is immediately obtained and shows 4 mm ST-segment elevation in leads V2, V3, and V4. The facility has a cardiac catheterization lab that is currently available and staffed. The estimated door-to-balloon time is 60 minutes.

    Which of the following is the most appropriate next step in the management of this patient?

    Show answer & explanation

    Correct answer: C

    The patient has a clear ST-segment elevation myocardial infarction (STEMI). According to AHA guidelines, the preferred reperfusion strategy is primary PCI if it can be performed within 90 minutes of first medical contact (or 120 minutes of first medical contact if transfer is required). Since the facility has an available cath lab and the estimated door-to-balloon time is 60 minutes, this is the superior option over fibrinolysis. Pain management with nitroglycerin and morphine should be done concurrently, but activating the cath lab is the time-critical priority.

  5. Question 5Beginner

    Airway Management · Ventilation during CPR with Advanced Airway

    A patient in cardiac arrest has been intubated with an endotracheal tube. The ventilator is set to deliver 10 breaths per minute. During CPR, chest compressions should be performed at a rate of 100-120 per minute and be ______ with ventilations.

    Show answer & explanation

    Correct answer: C

    Once an advanced airway (like an endotracheal tube) is in place, chest compressions and ventilations are performed asynchronously. Compressions are continuous at a rate of 100-120 per minute, and one breath is given every 6 seconds (10 breaths per minute) without pausing compressions. This maximizes perfusion by maintaining a high chest compression fraction.

  6. Question 6IntermediateSelect 3

    Systems of Care · Chain of Survival

    The sixth and newest link added to the Adult Chain of Survival in the 2020 AHA Guidelines is 'Recovery'. Which of the following elements are essential components of this new link? (Select ALL that apply)

    Show answer & explanation

    Correct answers: A, C, D

    The Recovery link emphasizes a holistic approach, including mental and emotional health screening for survivors and their families.

    Physical recovery and rehabilitation are core components of the long-term recovery process.

    This ensures a smooth transition from hospital to home and addresses all aspects of the patient's recovery needs.

  7. Question 7Beginner

    Cardiac Arrest Algorithm · Antiarrhythmic Dosing

    A 40-year-old patient is in refractory ventricular fibrillation despite multiple shocks and 300 mg of amiodarone. The team is considering an alternative antiarrhythmic. What is the correct initial dose of lidocaine for this situation?

    Show answer & explanation

    Correct answer: B

    For refractory VF/pVT, lidocaine can be used as an alternative to amiodarone. The correct initial dose is 1 to 1.5 mg/kg IV push. If needed, a second dose of 0.5 to 0.75 mg/kg can be given.

  8. Question 8Intermediate

    Tachycardia Management · Stable SVT Algorithm

    A conscious and alert 30-year-old female presents with a regular, narrow-complex tachycardia at 170 bpm. Her blood pressure is 110/70 mmHg. Vagal maneuvers are ineffective. Which sequence of interventions is most appropriate according to the ACLS tachycardia algorithm?

    Client → Provider → Intervention
    | | |
    |—HR 170 bpm—→| |
    | |—Vagal Maneuver—→| (No Change)
    | | |
    | |—[Next Step?]———→|

    Show answer & explanation

    Correct answer: C

    The patient is stable with a regular, narrow-complex tachycardia, which is presumed to be supraventricular tachycardia (SVT). After vagal maneuvers fail, the first-line pharmacologic agent is adenosine. It should be administered as a 6 mg rapid IV push. If the rhythm does not convert, a second dose of 12 mg may be given. Cardioversion is reserved for unstable patients.

  9. Question 9Intermediate

    High-Quality CPR and BLS · Capnography in ROSC

    A team is resuscitating a patient from cardiac arrest. After 10 minutes of high-quality CPR and appropriate drug administration, there is a sudden and sustained increase in the ETCO2 reading from 12 mmHg to 45 mmHg. What is the most likely cause of this change?

    Show answer & explanation

    Correct answer: C

    A rapid and sustained jump in ETCO2 (typically to >40 mmHg) is a strong indicator of Return of Spontaneous Circulation (ROSC). When the heart starts beating effectively again, it pumps the accumulated CO2 from the tissues to the lungs, causing a sharp rise in the exhaled CO2 level. This is often the earliest sign of ROSC, preceding a palpable pulse.

Ready for the real thing?

The full ACLS simulator has every exam-style question, timed mode, and instant scoring.

Go to the ACLS simulator →